Round 7: Tossup 8

According to the Knudson hypothesis, genes named for countering these structures require “two hits” to deactivate. During inflammation, macrophages secrete a cytokine (“SIGH-toh-kyne”) known as these structures’ namesake “necrosis factor.” These structures, whose namesake suppressor genes include the “guardian (15[1])angel of the genome” (*) p53 (10[1])(“P-fifty-three”), are also known (-5[1])as neoplasms. The first immortal human cell line, HeLa (10[1])(“hee-lah”) cells, were extracted from (10[1])one of these structures (10[2])in the cervix. These structures (10[2])can be benign or (10[1])malignant (10[3])depending (10[2])on (10[1])if they spread or not, a process known as metastasis. For 10 points, name these abnormal cell growths that may be cancerous. ■END■ (10[1])

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