Round 7: Tossup 8

According to the Knudson hypothesis, genes named for countering these structures require “two hits” to deactivate. (15[2])During inflammation, macrophages (15[1])secrete a cytokine (“SIGH-toh-kyne”) known as these structures’ namesake “necrosis factor.” These structures, (15[1])whose namesake suppressor genes include the “guardian angel of the genome” (*) p53 (“P-fifty-three”), are also known (-5[1])as neoplasms. The first immortal human cell line, HeLa (“hee-lah”) cells, were extracted from one of these structures in the cervix. These structures can be benign or malignant depending on if they spread or not, (10[1])a process known as metastasis. For 10 points, name these abnormal cell growths that may be cancerous. ■END■

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